Mathematics of Developing and Proving Efficiency of Sterilization Process

Sterilization is the process of destroying all microorganisms and their pathogenic products. The different sterilization techniques include, dry heat sterilization, steam sterilization, radiation sterilization and more. During sterilization, different microorganisms in different environments possess different resistance to the destructive principles that causes the organism or spore to die (lethality). D-value is the term used to describe the amount of time required to kill or destroy a microorganism. The Z-value allows integration of the lethal effect of heat as the temperature changes during the heating and cooling phases of a sterilization cycle. To learn more on the mathematical means of developing and proving that the sterilization process is effective and does not generate a problem for heat liable products --- visit the link Mathematicsof Terminal Sterilization - Probability of Survival Approach -vs- Overkill Approach